ID   BCLC-5-C8.1/miR122
AC   CVCL_C8JN
DR   Wikidata; Q123030776
RX   PubMed=28751105;
CC   Characteristics: Transfected with a construct containing a neomycin resistance selectable marker (SGR-JFH1-neo) and cured of HCV RNA by interferon-alpha treatment and with a construct containing miR122 and GFP (PubMed=28751105).
CC   Virology: Exhibits enhanced hepatitis C virus (HCV) RNA replication compared to parent cell line (PubMed=28751105).
CC   Genetic integration: Method=Transfection; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:31501; MIR122.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Epithelial cell; CL=CL_0000066.
DI   NCIt; C3098; Hepatitis C infection
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   NCIt; C2951; Cirrhosis
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C8JL ! BCLC-5-C8.1
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 05-10-23; Last updated: 10-04-25; Version: 5
//
RX   PubMed=28751105; DOI=10.1016/j.virusres.2017.07.018;
RA   Coto-Llerena M., Koutsoudakis G., Boix L., Lopez-Oliva J.M.,
RA   Caro-Perez N., Fernandez-Carrillo C., Gonzalez P., Gastaminza P.,
RA   Bruix J., Forns X., Perez-del-Pulgar S.;
RT   "Permissiveness of human hepatocellular carcinoma cell lines for
RT   hepatitis C virus entry and replication.";
RL   Virus Res. 240:35-46(2017).
//