ID   TK 173
AC   CVCL_C8FA
SY   Tk 173; TK-173; tNKF; transformed Normal Kidney Fibroblasts
DR   Wikidata; Q123033618
RX   PubMed=7773632;
RX   PubMed=11702000;
RX   PubMed=12684791;
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pSV3-gpt).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
CC   Cell type: Renal interstitial fibroblast; CL=CL_1000692.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 29-06-23; Last updated: 10-04-25; Version: 5
//
RX   PubMed=7773632;
RA   Muller G.A., Frank J., Rodemann H.P., Engler-Blum G.;
RT   "Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to
RT   investigate pathophysiologic mechanisms of renal interstitial
RT   fibrosis.";
RL   Exp. Nephrol. 3:127-133(1995).
//
RX   PubMed=11702000; DOI=10.1159/000052639;
RA   Grunewald R.W., Ehrhard M., Fiedler G.M., Schuttert J.B.,
RA   Oppermann M., Muller G.A.;
RT   "Evidence for a sorbitol transport system in immortalized human renal
RT   interstitial cells.";
RL   Exp. Nephrol. 9:405-411(2001).
//
RX   PubMed=12684791; DOI=10.1007/s00424-003-1026-y;
RA   Schuttert J.B., Liu M.H., Gliem N., Fiedler G.M., Zopf S., Mayer C.,
RA   Muller G.A., Grunewald R.W.;
RT   "Human renal fibroblasts derived from normal and fibrotic kidneys show
RT   differences in increase of extracellular matrix synthesis and cell
RT   proliferation upon angiotensin II exposure.";
RL   Pflugers Arch. 446:387-393(2003).
//