ID   MM418
AC   CVCL_C843
SY   MM 418; 418
DR   cancercelllines; CVCL_C843
DR   ChEMBL-Cells; CHEMBL3307300
DR   ChEMBL-Targets; CHEMBL614131
DR   Cosmic; 928707
DR   GEO; GSM226682
DR   Progenetix; CVCL_C843
DR   PubChem_Cell_line; CVCL_C843
DR   Wikidata; Q54906127
RX   PubMed=1697409;
RX   PubMed=2798324;
RX   PubMed=2798328;
RX   PubMed=3127479;
RX   PubMed=3756862;
RX   PubMed=4059365;
RX   PubMed=7520026;
RX   PubMed=9354451;
RX   PubMed=17363583;
CC   Characteristics: Highly pigmented.
CC   Doubling time: 35.8 hours (PubMed=2798324).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17363583).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17363583).
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Back, skin; UBERON=UBERON_0001068.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=1697409;
RA   Chenevix-Trench G., Martin N.G., Ellem K.A.O.;
RT   "Gene expression in melanoma cell lines and cultured melanocytes:
RT   correlation between levels of c-src-1, c-myc and p53.";
RL   Oncogene 5:1187-1193(1990).
//
RX   PubMed=2798324; DOI=10.1111/j.1600-0749.1989.tb00211.x;
RA   Brown J.K., Mountford M.H., Allen B.J., Mishima Y., Ichihashi M.,
RA   Parsons P.G.;
RT   "Neutron irradiation of human melanoma cells.";
RL   Pigment Cell Res. 2:319-324(1989).
//
RX   PubMed=2798328; DOI=10.1111/j.1600-0749.1989.tb00217.x;
RA   Barkla D.H., Allen B.J., Brown J.K., Mountford M.H., Mishima Y.,
RA   Ichihashi M.;
RT   "Morphological changes in human melanoma cells following irradiation
RT   with thermal neutrons.";
RL   Pigment Cell Res. 2:345-348(1989).
//
RX   PubMed=3127479; DOI=10.1111/1523-1747.ep12461022;
RA   McEwan M., Parsons P.G., Moss D.J.;
RT   "Monoclonal antibody against human tyrosinase and reactive with
RT   melanotic and amelanotic melanoma cells.";
RL   J. Invest. Dermatol. 90:515-519(1988).
//
RX   PubMed=3756862;
RA   Maynard K., Parsons P.G.;
RT   "Cross-sensitivity of methylating agents, hydroxyurea, and
RT   methotrexate in human tumor cells of the Mer- phenotype.";
RL   Cancer Res. 46:5009-5013(1986).
//
RX   PubMed=4059365; DOI=10.1111/j.1751-1097.1985.tb08944.x;
RA   Parsons P.G., Hayward I.P.;
RT   "Inhibition of DNA repair synthesis by sunlight.";
RL   Photochem. Photobiol. 42:287-293(1985).
//
RX   PubMed=7520026; DOI=10.1002/ijc.2910580413;
RA   Hersey P., Si Z.-Y., Smith M.J., Thomas W.D.;
RT   "Expression of the co-stimulatory molecule B7 on melanoma cells.";
RL   Int. J. Cancer 58:527-532(1994).
//
RX   PubMed=9354451;
RA   Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M.,
RA   Gabrielli B.G., Parsons P.G., Hayward N.K.;
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152;
RA   Stark M.S., Hayward N.K.;
RT   "Genome-wide loss of heterozygosity and copy number analysis in
RT   melanoma using high-density single-nucleotide polymorphism arrays.";
RL   Cancer Res. 67:2632-2642(2007).
//