ID   Ma-Mel-86f
AC   CVCL_C7TQ
DR   GEO; GSM2135606
DR   Progenetix; CVCL_C7TQ
DR   Wikidata; Q117704639
RX   PubMed=27261508;
CC   Characteristics: Has lost HLA class I surface expression due to the deletion of B2M (PubMed=27261508).
CC   Sequence variation: Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Homozygous (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24His (c.71G>A); ClinVar=VCV000016929; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro193Ser (c.577C>T); dbSNP=rs1595884713; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs (c.633_645delAGATCCTCAGTTT); Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.741_742delinsTT) (c.741_742CC>TT); ClinVar=VCV000437017; Zygosity=Unspecified (PubMed=27261508).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4225; Cutaneous nodular melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A221 ! Ma-Mel-86a
OI   CVCL_A222 ! Ma-Mel-86b
OI   CVCL_C7TP ! Ma-Mel-86c
SX   Female
AG   40Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 10-04-25; Version: 6
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RX   PubMed=27261508; DOI=10.1158/0008-5472.CAN-16-0008;
RA   Zhao F., Sucker A., Horn S., Heeke C., Bielefeld N., Schrors B.,
RA   Bicker A., Lindemann M., Roesch A., Gaudernack G., Stiller M.,
RA   Becker J.C., Lennerz V., Wolfel T., Schadendorf D., Griewank K.G.,
RA   Paschen A.;
RT   "Melanoma lesions independently acquire T-cell resistance during
RT   metastatic latency.";
RL   Cancer Res. 76:4347-4358(2016).
//