ID   Ma-Mel-86c
AC   CVCL_C7TP
DR   GEO; GSM2135605
DR   Progenetix; CVCL_C7TP
DR   Wikidata; Q117704638
RX   PubMed=27261508;
CC   HLA typing: A*01:01; B*08:01; C*07:01 (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24His (c.71G>A); ClinVar=VCV000016929; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:6840; MAP2K1; Simple; p.Pro193Ser (c.577C>T); dbSNP=rs1595884713; Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Asn212fs (c.633_645delAGATCCTCAGTTT); Zygosity=Unspecified (PubMed=27261508).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.741_742delinsTT) (c.741_742CC>TT); ClinVar=VCV000437017; Zygosity=Unspecified (PubMed=27261508).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C4225; Cutaneous nodular melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_A221 ! Ma-Mel-86a
OI   CVCL_A222 ! Ma-Mel-86b
OI   CVCL_C7TQ ! Ma-Mel-86f
SX   Female
AG   37Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 10-04-25; Version: 6
//
RX   PubMed=27261508; DOI=10.1158/0008-5472.CAN-16-0008;
RA   Zhao F., Sucker A., Horn S., Heeke C., Bielefeld N., Schrors B.,
RA   Bicker A., Lindemann M., Roesch A., Gaudernack G., Stiller M.,
RA   Becker J.C., Lennerz V., Wolfel T., Schadendorf D., Griewank K.G.,
RA   Paschen A.;
RT   "Melanoma lesions independently acquire T-cell resistance during
RT   metastatic latency.";
RL   Cancer Res. 76:4347-4358(2016).
//