ID   MCF10A-ERBB2m-1
AC   CVCL_C7QP
SY   MCF10A-ERBB2_type-01; 06M15006
DR   CancerTools; 161190
DR   Wikidata; Q117704667
RX   PubMed=30787176;
WW   Info; FTRP; -; https://www.fmu.ac.jp/home/trc/en/contract-research-provision/human-gene-overexpressing-cell-lines/
CC   Part of: Fukushima Translational Research Project gene-overexpressing cell lines panel.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3430; ERBB2 (Note=With p.Gly309Ala (c.926G>C)).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0598 ! MCF-10A
SX   Female
AG   36Y
CA   Spontaneously immortalized cell line
DT   Created: 21-03-23; Last updated: 10-04-25; Version: 5
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RX   PubMed=30787176; DOI=10.1158/1535-7163.MCT-18-1085;
RA   Irie, Hiroki
RA   Ito, Kimihiro
RA   Fujioka, Yayoi
RA   Oguchi, Kei
RA   Fujioka, Akio
RA   Hashimoto, Akihiro
RA   Ohsawa, Hirokazu
RA   Tanaka, Kenji
RA   Funabashi, Kaoru
RA   Araki, Hikari
RA   Kawai, Yuichi
RA   Shimamura, Tadashi
RA   Wadhwa, Renu
RA   Ohkubo, Shuichi
RA   Matsuo, Kenichi
RT   "TAS0728, a covalent-binding, HER2-selective kinase inhibitor shows
RT   potent antitumor activity in preclinical models.";
RL   Mol. Cancer Ther. 18:733-742(2019).
//