ID   DKFZ-BT308
AC   CVCL_C7GU
DR   Wikidata; Q117704285
RX   PubMed=35977048;
CC   Characteristics: Transduced with a doxycycline-inducible system coding for SV40 large T antigen and GFP (PubMed=35977048).
CC   Senescence: Withdrawal of doxycyclin leads to senescence (PubMed=35977048).
CC   Sequence variation: Gene fusion; HGNC; HGNC:1097; BRAF + HGNC; HGNC:22219; KIAA1549; Name(s)=KIAA1549-BRAF (PubMed=35977048).
CC   Genetic integration: Method=Transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C4047; Pilocytic astrocytoma
DI   ORDO; Orphanet_251612; Pilocytic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   5Y
CA   Cancer cell line
DT   Created: 21-03-23; Last updated: 19-12-24; Version: 4
//
RX   PubMed=35977048; DOI=10.1093/neuonc/noac199; PMCID=PMC10076946;
RA   Selt F., Sigaud R., Valinciute G., Sievers P., Zaman J., Alco C.,
RA   Schmid S., Peterziel H., Tsai J.W., Guiho R., Martinez-Barbera J.P.,
RA   Pusch S., Deng J., Zhai Y.-F., van Tilburg C.M., Schuhmann M.U.,
RA   El Damaty A., Bandopadhayay P., Herold-Mende C., von Deimling A.,
RA   Pfister S.M., Montero J., Capper D., Oehme I., Sahm F., Jones D.T.W.,
RA   Witt O., Milde T.;
RT   "BH3 mimetics targeting BCL-XL impact the senescent compartment of
RT   pilocytic astrocytoma.";
RL   Neuro-oncol. 25:735-747(2023).
//