ID   U87MG/ALDH1A3-KO.1
AC   CVCL_C6IK
DR   Wikidata; Q116050660
RX   PubMed=34934174;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 409; ALDH1A3.
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 05-10-23; Version: 3
//
RX   PubMed=34934174; DOI=10.1038/s42003-021-02949-7;
RA   Li J.-F., Garavaglia S., Ye Z.-F., Moretti A., Belyaeva O.V.,
RA   Beiser A., Ibrahim M., Wilk A., McClellan S., Klyuyeva A.V.,
RA   Goggans K.R., Kedishvili N.Y., Salter E.A., Wierzbicki A.,
RA   Migaud M.E., Mullett S.J., Yates N.A., Camacho C.J., Rizzi M.,
RA   Sobol R.W.;
RT   "A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis
RT   in glioma stem cells.";
RL   Commun. Biol. 4:1420.1-1420.16(2021).
//