ID   FM74
AC   CVCL_C603
SY   FM-74
DR   cancercelllines; CVCL_C603
DR   Cosmic; 808559
DR   Cosmic; 1047675
DR   ECACC; 13012422
DR   ESTDAB; ESTDAB-022
DR   GEO; GSM156015
DR   IARC_TP53; 26101
DR   Progenetix; CVCL_C603
DR   Wikidata; Q54835061
RX   PubMed=7656272;
RX   PubMed=8968104;
RX   PubMed=15592718;
RX   PubMed=17260012;
CC   HLA typing: A*31:01:02,24:02; B*15:01:01:01,35:01; C*03:03,04:01:01; DPB1*04:01; DQB1*03:02,05:01; DRB1*01:01,04:01:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Unspecified (PubMed=17260012).
CC   Omics: Variations; Array-based CGH.
ST   Source(s): ECACC=13012422; ESTDAB=ESTDAB-022
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 8,9 (ECACC=13012422)
ST   D13S317: 12 (ESTDAB=ESTDAB-022)
ST   D16S539: 12
ST   D3S1358: 15,16
ST   D5S818: 12,13 (ECACC=13012422)
ST   D5S818: 13 (ESTDAB=ESTDAB-022)
ST   D7S820: 8,9 (ECACC=13012422)
ST   D7S820: 8,10 (ESTDAB=ESTDAB-022)
ST   FGA: 20,21
ST   TH01: 9.3
ST   TPOX: 9,12
ST   vWA: 16,17
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 20
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=7656272; DOI=10.1007/BF01527402; PMCID=PMC11037630;
RA   Kirkin, Alexei F.
RA   Petersen, Troels Reichert
RA   Olsen, Anna Catharina
RA   Li, Li
RA   thor Straten, Per
RA   Zeuthen, Jesper
RT   "Generation of human-melanoma-specific T lymphocyte clones defining
RT   novel cytolytic targets with panels of newly established melanoma cell
RT   lines.";
RL   Cancer Immunol. Immunother. 41:71-81(1995).
//
RX   PubMed=8968104;
RA   Bartkova, Jirina
RA   Lukas, Jiri
RA   Guldberg, Per
RA   Alsner, Jan
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RA   Bartek, Jiri
RT   "The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently
RT   altered in melanoma pathogenesis.";
RL   Cancer Res. 56:5475-5483(1996).
//
RX   PubMed=17260012; DOI=10.1038/sj.onc.1210252;
RA   Jonsson, Goran
RA   Dahl, Christina
RA   Staaf, Johan
RA   Sandberg, Troy
RA   Bendahl, Par-Ola
RA   Ringner, Markus
RA   Guldberg, Per
RA   Borg, Ake
RT   "Genomic profiling of malignant melanoma using tiling-resolution
RT   arrayCGH.";
RL   Oncogene 26:4738-4748(2007).
//