ID   HeLa-C3
AC   CVCL_C5RL
SY   HeLa C3
DR   ChEMBL-Cells; CHEMBL3886021
DR   Wikidata; Q116049309
RX   CelloPub=CLPUB00727;
RX   PubMed=9374378;
CC   Population: African American.
CC   Characteristics: Obtained from the parent cell line that was subjected to 3 cycles of 10 Gy of Ce-137 irradiation (CelloPub=CLPUB00727; PubMed=9374378).
CC   Doubling time: 20.5-23 hours (PubMed=9374378).
CC   Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Transformant: NCIt; C129643; Cesium-137 gamma radiation.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 10-04-25; Version: 6
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RX   CelloPub=CLPUB00727;
RA   Eichholtz-Wirth H., Stoetzer O.J., Marx K.;
RT   "Radiation-induced cisplatin resistance in two human cell lines.";
RL   Radioprotection 32:139-140(1997).
//
RX   PubMed=9374378; DOI=10.1038/bjc.1997.555; PMCID=PMC2228159;
RA   Eichholtz-Wirth H., Stoetzer O.J., Marx K.;
RT   "Reduced expression of the ICE-related protease CPP32 is associated
RT   with radiation-induced cisplatin resistance in HeLa cells.";
RL   Br. J. Cancer 76:1322-1327(1997).
//