ID   SH-39-HOM
AC   CVCL_C585
DR   ESTDAB; ESTDAB-060
DR   Wikidata; Q54953203
RX   PubMed=15592718;
WW   Info; ESTDAB; ESTDAB-060; https://web.archive.org/web/20160416070743/http://www.ebi.ac.uk/cgi-bin/ipd/estdab/print_cell.cgi?ESTDAB-060
CC   Problematic cell line: Probably contaminated. The STR profile and HLA typing information are nearly identical to that of the A-549 cell line. Originally thought to originate from a melanoma patient along with a sister cell line, RE-25-HOM (Cellosaurus=CVCL_C577).
CC   Population: Caucasian.
CC   HLA typing: A*25:01,30:01; B*18:01,44:03:01; C*12:03,16:01; DPB1*03:01,16:01; DQB1*03:01:01,02:01; DRB1*11:03:01,07:01 (PubMed=15592718).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): ESTDAB=ESTDAB-060
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 11
ST   D3S1358: 16
ST   D5S818: 11
ST   D7S820: 8,11
ST   FGA: 23
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 14
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 27-11-25; Version: 10
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RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//