ID   RBL SX-38
AC   CVCL_C4MP
SY   RBL-SX38; RBL-2H3-SX38; SX-38
DR   Wikidata; Q116050162
RX   PubMed=8683119;
RX   PubMed=12609531;
RX   PubMed=18534732;
RX   PubMed=19538351;
RX   PubMed=25149487;
CC   Biotechnology: Can be used in human allergy assays. Because it expresses human Fc-epsilon RI, following sensitization with IgE from a subset of allergic donors, these cells can be triggered by exposure to anti-IgE or to very low concentrations of specific allergen.
CC   Transfected with: HGNC; 3609; FCER1A.
CC   Transfected with: HGNC; 7316; MS4A2.
CC   Transfected with: HGNC; 3611; FCER1G.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Breed/subspecies: Wistar.
DI   NCIt; C60428; Rat leukemia
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
HI   CVCL_0591 ! RBL-2H3
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
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RX   PubMed=8683119; DOI=10.4049/jimmunol.157.1.221;
RA   Wiegand T.W., Williams P.B., Dreskin S.C., Jouvin M.-H., Kinet J.-P.,
RA   Tasset D.;
RT   "High-affinity oligonucleotide ligands to human IgE inhibit binding to
RT   Fc epsilon receptor I.";
RL   J. Immunol. 157:221-230(1996).
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RX   PubMed=12609531; DOI=10.1016/S0022-1759(02)00369-1;
RA   Dibbern D.A. Jr., Palmer G.W., Williams P.B., Bock S.A., Dreskin S.C.;
RT   "RBL cells expressing human Fc epsilon RI are a sensitive tool for
RT   exploring functional IgE-allergen interactions: studies with sera from
RT   peanut-sensitive patients.";
RL   J. Immunol. Methods 274:37-45(2003).
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RX   PubMed=18534732; DOI=10.1016/j.yrtph.2008.04.012;
RA   Ladics G.S., van Bilsen J.H.M., Brouwer H.M.H., Vogel L., Vieths S.,
RA   Knippels L.M.J.;
RT   "Assessment of three human FcepsilonRI-transfected RBL cell-lines for
RT   identifying IgE induced degranulation utilizing peanut-allergic
RT   patient sera and peanut protein extract.";
RL   Regul. Toxicol. Pharmacol. 51:288-294(2008).
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RX   PubMed=19538351; DOI=10.1111/j.1365-2222.2009.03294.x;
RA   Blanc F., Adel-Patient K., Drumare M.-F., Paty E., Wal J.-M.,
RA   Bernard H.;
RT   "Capacity of purified peanut allergens to induce degranulation in a
RT   functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient
RT   elicitors.";
RL   Clin. Exp. Allergy 39:1277-1285(2009).
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RX   PubMed=25149487; DOI=10.1007/978-1-4939-1173-8_8;
RA   Passante E.;
RT   "Mast cell and basophil cell lines: a compendium.";
RL   Methods Mol. Biol. 1192:101-113(2014).
//