ID   MUC-1
AC   CVCL_C4KG
DR   Wikidata; Q116049809
RX   PubMed=27764813;
RX   PubMed=33981288;
RX   PubMed=35563746;
CC   Characteristics: Established from a patient-derived xenograft also called MUC-1.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg342Glufs*3 (c.1024delC); ClinVar=VCV000428885; Zygosity=Unspecified (PubMed=27764813).
CC   Omics: Genomics; Whole genome sequencing.
CC   Derived from site: Metastatic; Neck, hypodermis; UBERON=UBERON_0000974+UBERON_0002072.
ST   Source(s): PubMed=27764813
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D12S391: 19.3,22
ST   D13S317: 9
ST   D16S539: 11,14
ST   D18S51: 14,18
ST   D19S433: 13,14
ST   D1S1656: 15
ST   D21S11: 29
ST   D2S1338: 26
ST   D3S1358: 16,18
ST   D5S818: 11
ST   D6S1043: 12
ST   D7S820: 8,10
ST   D8S1179: 8
ST   FGA: 22,23.2
ST   Penta D: 9
ST   Penta E: 7,13
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C9325; Adrenal cortex carcinoma
DI   ORDO; Orphanet_1501; Adrenocortical carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   24Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 10-04-25; Version: 5
//
RX   PubMed=27764813; DOI=10.18632/oncotarget.12685; PMCID=PMC5346714;
RA   Hantel C., Shapiro I., Poli G., Chiapponi C., Bidlingmaier M.,
RA   Reincke M., Luconi M., Jung S., Beuschlein F.;
RT   "Targeting heterogeneity of adrenocortical carcinoma: evaluation and
RT   extension of preclinical tumor models to improve clinical
RT   translation.";
RL   Oncotarget 7:79292-79304(2016).
//
RX   PubMed=33981288; DOI=10.3389/fendo.2021.669426; PMCID=PMC8108132;
RA   Rossini E., Tamburello M., Abate A., Beretta S., Fragni M.,
RA   Cominelli M., Cosentini D., Hantel C., Bono F., Grisanti S.,
RA   Poliani P.L., Tiberio G.A.M., Memo M., Sigala S., Berruti A.;
RT   "Cytotoxic effect of progesterone, tamoxifen and their combination in
RT   experimental cell models of human adrenocortical cancer.";
RL   Front. Endocrinol. 12:669426.1-669426.13(2021).
//
RX   PubMed=35563746; DOI=10.3390/cells11091439; PMCID=PMC9103477;
RA   Sigala S., Bothou C., Penton D., Abate A., Peitzsch M., Cosentini D.,
RA   Tiberio G.A.M., Bornstein S.R., Berruti A., Hantel C.;
RT   "A comprehensive investigation of steroidogenic signaling in classical
RT   and new experimental cell models of adrenocortical carcinoma.";
RL   Cells 11:1439.1-1439.17(2022).
//