ID   SKOV3.ip1 PEA-15-DD
AC   CVCL_C4JA
SY   SKOV3.ip1-DD
DR   Wikidata; Q116050516
RX   PubMed=23552738;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 8822; PEA15 (with p.Ser104Asp and p.Ser116Asp and a N-terminal HA tag).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0C84 ! SKOV3.ip1
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 29-06-23; Version: 3
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RX   PubMed=23552738; DOI=10.1038/oncsis.2012.22;
RA   Lee J., Bartholomeusz C., Krishnamurthy S., Liu P., Saso H.,
RA   LaFortune T.A., Hortobagyi G.N., Ueno N.T.;
RT   "PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits
RT   ovarian cancer cell tumorigenicity and progression through blocking
RT   beta-catenin.";
RL   Oncogenesis 1:e22.1-e22.11(2012).
//