ID   HAP1 PFN1 (-) 3
AC   CVCL_C4J6
SY   HZGHC005831c016; PFN1 knockout cell line 7bp deletion
DR   Horizon_Discovery; HZGHC005831c016
DR   Wikidata; Q116049282
RX   PubMed=37576538;
CC   Group: Haploid karyotype cell line.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:8881; PFN1.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_Y019 ! HAP1
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 15-12-22; Last updated: 19-12-24; Version: 6
//
RX   PubMed=37576538; DOI=10.12688/f1000research.132249.1; PMCID=PMC10415725;
RA   Ayoubi R., McDowell I., Fotouhi M., Southern K., McPherson P.S.,
RA   Laflamme C.;
RG   ABIF Consortium;
RG   NeuroSGC/YCharOS Collaborative Group;
RT   "The identification of high-performing antibodies for profilin-1 for use
RT   in western blot, immunoprecipitation and immunofluorescence.";
RL   F1000Research 12:348.1-348.10(2023).
//