ID   CP-B
AC   CVCL_C452
SY   CP-B hTRT; CP-52731 hTERT; ChTERT
DR   ATCC; CRL-4028
DR   BioSample; SAMN03471731
DR   Wikidata; Q54814363
RX   PubMed=12807723;
CC   Doubling time: ~34 hours (ATCC=CRL-4028).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Leu97Gln (c.290T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Esophagus; UBERON=UBERON_0001043.
CC   Cell type: Epithelial cell of esophagus; CL=CL_0002252.
ST   Source(s): ATCC=CRL-4028
ST   Amelogenin: X,Y
ST   CSF1PO: 8,12
ST   D13S317: 8,12
ST   D16S539: 10,13
ST   D18S51: 12,21
ST   D19S433: 13,14
ST   D21S11: 30
ST   D2S1338: 23,25
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 22
ST   Penta D: 13
ST   Penta E: 17,19
ST   TH01: 8,9
ST   TPOX: 8,9
ST   vWA: 18,20
DI   NCIt; C2891; Barrett esophagus
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A8WE ! CP-52731
SX   Male
AG   Adult
CA   Telomerase immortalized cell line
DT   Created: 22-10-12; Last updated: 19-12-24; Version: 15
//
RX   PubMed=12807723; DOI=10.1093/carcin/bgg076; PMCID=PMC1559990;
RA   Palanca-Wessels M.C.A., Klingelhutz A.J., Reid B.J., Norwood T.H.,
RA   Opheim K.E., Paulson T.G., Feng Z.-D., Rabinovitch P.S.;
RT   "Extended lifespan of Barrett's esophagus epithelium transduced with
RT   the human telomerase catalytic subunit: a useful in vitro model.";
RL   Carcinogenesis 24:1183-1190(2003).
//