ID   409B2 HCN4-EGFP/SHOX2-mCherry
AC   CVCL_C3LU
DR   Wikidata; Q116048197
RX   PubMed=36092505;
CC   Population: Caucasian.
CC   Characteristics: Dual reporter cell line. Using homologous recombination EGFP was inserted at the N-terminus of HCN4 and using CRISPR/Cas9 mCherry was inserted at the N-terminus of SHOX2 (PubMed=36092505).
CC   Genetic integration: Method=CRISPR/Cas9; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
CC   Genetic integration: Method=Homologous recombination; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_K092 ! 409B2
SX   Female
AG   36Y
CA   Induced pluripotent stem cell
DT   Created: 15-12-22; Last updated: 10-09-24; Version: 4
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RX   PubMed=36092505; DOI=10.1016/j.reth.2022.07.012; PMCID=PMC9420958;
RA   Wakimizu T., Morikawa K., Fukumura K., Yuki T., Adachi T., Kurata Y.,
RA   Miake J., Hisatome I., Tsuneto M., Shirayoshi Y.;
RT   "SHOX2 refines the identification of human sinoatrial nodal cell
RT   population in the in vitro cardiac differentiation.";
RL   Regen. Ther. 21:239-249(2022).
//