ID   1321N1 RHOA KO
SY   1321N1-Rho KO
DR   cancercelllines; CVCL_C3IR
DR   GEO; GSM3034471
DR   GEO; GSM3034472
DR   Wikidata; Q114310344
RX   PubMed=29887596;
CC   Problematic cell line: Contaminated. Ancestral cell line (U-118MG) has been shown to be a U-138MG derivative.
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 667; RHOA.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0110 ! 1321N1
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
RX   PubMed=29887596; DOI=10.1038/s41388-018-0301-5;
RA   Yu O.M., Benitez J.A., Plouffe S.W., Ryback D., Klein A., Smith J.,
RA   Greenbaum J., Delatte B., Rao A., Guan K.-L., Furnari F.B., Chaim O.M.,
RA   Miyamoto S., Brown J.H.;
RT   "YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene
RT   expression, are critical for glioblastoma tumorigenicity.";
RL   Oncogene 37:5492-5507(2018).