SY   NOX2-KO PLB-985; NOX2-/- PLB-985; gp91Phox targeted PLB-985
DR   GEO; GSM2690934
DR   GEO; GSM2690935
DR   GEO; GSM2690936
DR   GEO; GSM2690937
DR   GEO; GSM2690938
DR   GEO; GSM2690939
DR   GEO; GSM2690940
DR   GEO; GSM2690941
DR   GEO; GSM2690942
DR   GEO; GSM2690943
DR   GEO; GSM2690944
DR   Wikidata; Q114312663
RX   PubMed=8234321;
RX   PubMed=29967760;
CC   Problematic cell line: Contaminated. Parent cell line (PLB-985) was shown to be a HL-60 derivative.
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; 2578; CYBB.
CC   Sequence variation: Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9154; Adult acute myeloid leukemia
DI   ORDO; Orphanet_519; Acute myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2162 ! PLB-985
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 29-06-23; Version: 4
RX   PubMed=8234321; DOI=10.1073/pnas.90.21.9832;
RA   Zhen L., King A.A.J., Xiao Y.-H., Chanock S.J., Orkin S.H., Dinauer M.C.;
RT   "Gene targeting of X chromosome-linked chronic granulomatous disease
RT   locus in a human myeloid leukemia cell line and rescue by expression
RT   of recombinant gp91phox.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:9832-9836(1993).
RX   PubMed=29967760; DOI=10.3389/fonc.2018.00218;
RA   Kiffin R., Wiktorin H.G., Nilsson M.S., Aurelius J., Aydin E., Lenox B.,
RA   Nilsson J.A., Stahlberg A., Thoren F.B., Hellstrand K., Martner A.;
RT   "Anti-leukemic properties of histamine in monocytic leukemia: the role
RT   of NOX2.";
RL   Front. Oncol. 8:218.1-218.12(2018).