ID   PLB-985 CYBB KO
AC   CVCL_C3HD
SY   NOX2-KO PLB-985; NOX2-/- PLB-985; gp91Phox targeted PLB-985
DR   cancercelllines; CVCL_C3HD
DR   GEO; GSM2690934
DR   GEO; GSM2690935
DR   GEO; GSM2690936
DR   GEO; GSM2690937
DR   GEO; GSM2690938
DR   GEO; GSM2690939
DR   GEO; GSM2690940
DR   GEO; GSM2690941
DR   GEO; GSM2690942
DR   GEO; GSM2690943
DR   GEO; GSM2690944
DR   Wikidata; Q114312663
RX   PubMed=8234321;
RX   PubMed=29967760;
CC   Problematic cell line: Contaminated. Parent cell line (PLB-985) was shown to be a HL-60 derivative.
CC   Population: Caucasian.
CC   Knockout cell: Method=Homologous recombination; HGNC; HGNC:2578; CYBB.
CC   Sequence variation: Gene deletion; HGNC; HGNC:11998; TP53; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C7961; Adult acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2162 ! PLB-985
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 14-08-25; Version: 9
//
RX   PubMed=29967760; DOI=10.3389/fonc.2018.00218; PMCID=PMC6015904;
RA   Kiffin, Roberta
RA   Wiktorin, Hanna Grauers
RA   Nilsson, Malin S.
RA   Aurelius, Johan
RA   Aydin, Ebru
RA   Lenox, Brianna
RA   Nilsson, Jonas A.
RA   Stahlberg, Anders
RA   Thoren, Fredrik Bergh
RA   Hellstrand, Kristoffer
RA   Martner, Anna
RT   "Anti-leukemic properties of histamine in monocytic leukemia: the role
RT   of NOX2.";
RL   Front. Oncol. 8:218.1-218.12(2018).
//
RX   PubMed=8234321; DOI=10.1073/pnas.90.21.9832; PMCID=PMC47666;
RA   Zhen, Ling
RA   King, Alexandra A.J.
RA   Xiao, Yong-Hong
RA   Chanock, Stephen Jacob
RA   Orkin, Stuart Holland
RA   Dinauer, Mary C.
RT   "Gene targeting of X chromosome-linked chronic granulomatous disease
RT   locus in a human myeloid leukemia cell line and rescue by expression
RT   of recombinant gp91phox.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:9832-9836(1993).
//