ID   Hep-G2-THRB MUT p.K155E;K411E
AC   CVCL_C3GE
SY   HepG2 RCCC-THRB mutant 15; rc15-TRbeta1
DR   cancercelllines; CVCL_C3GE
DR   GEO; GSM721684
DR   GEO; GSM721685
DR   GEO; GSM721686
DR   GEO; GSM721687
DR   GEO; GSM721688
DR   GEO; GSM721689
DR   Wikidata; Q114311602
RX   PubMed=21622534;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11799; THRB (Note=With p.Lys155Glu and p.Lys411Glu).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 10-04-25; Version: 8
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RX   PubMed=21622534; DOI=10.1210/me.2010-0420; PMCID=PMC3146248;
RA   Rosen M.D., Chan I.H., Privalsky M.L.;
RT   "Mutant thyroid hormone receptors (TRs) isolated from distinct cancer
RT   types display distinct target gene specificities: a unique regulatory
RT   repertoire associated with two renal clear cell carcinomas.";
RL   Mol. Endocrinol. 25:1311-1325(2011).
//