ID   Hep-G2-THRA
AC   CVCL_C3G9
SY   TRalpha1-WT
DR   cancercelllines; CVCL_C3G9
DR   GEO; GSM721654
DR   GEO; GSM721655
DR   GEO; GSM721656
DR   GEO; GSM721657
DR   GEO; GSM721658
DR   GEO; GSM721659
DR   Wikidata; Q114311593
RX   PubMed=19749797;
RX   PubMed=21622534;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11796; THRA.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 10-04-25; Version: 8
//
RX   PubMed=19749797; DOI=10.1038/onc.2009.265; PMCID=PMC2787677;
RA   Chan I.H., Privalsky M.L.;
RT   "Thyroid hormone receptor mutants implicated in human hepatocellular
RT   carcinoma display an altered target gene repertoire.";
RL   Oncogene 28:4162-4174(2009).
//
RX   PubMed=21622534; DOI=10.1210/me.2010-0420; PMCID=PMC3146248;
RA   Rosen M.D., Chan I.H., Privalsky M.L.;
RT   "Mutant thyroid hormone receptors (TRs) isolated from distinct cancer
RT   types display distinct target gene specificities: a unique regulatory
RT   repertoire associated with two renal clear cell carcinomas.";
RL   Mol. Endocrinol. 25:1311-1325(2011).
//