ID   Jurkat RB1-KO
AC   CVCL_C3G2
DR   cancercelllines; CVCL_C3G2
DR   GEO; GSM5534224
DR   GEO; GSM5534225
DR   GEO; GSM5534226
DR   GEO; GSM5534227
DR   GEO; GSM5534228
DR   GEO; GSM5534229
DR   Wikidata; Q114311802
RX   PubMed=33990344;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 9884; RB1.
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0065 ! Jurkat
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=33990344; DOI=10.1158/2159-8290.CD-20-1554;
RA   Lelliott E.J., Kong I.Y., Zethoven M., Ramsbottom K.M.,
RA   Martelotto L.G., Meyran D., Zhu J.J., Costacurta M., Kirby L.,
RA   Sandow J.J., Lim L., Dominguez P.M., Todorovski I., Haynes N.M.,
RA   Beavis P.A., Neeson P.J., Hawkins E.D., McArthur G.A., Parish I.A.,
RA   Johnstone R.W., Oliaro J., Sheppard K.E., Kearney C.J.,
RA   Vervoort S.J.;
RT   "CDK4/6 inhibition promotes antitumor immunity through the induction
RT   of T-cell memory.";
RL   Cancer Discov. 11:2582-2601(2021).
//