ID   A549 EGFR Biosensor
AC   CVCL_C3ET
SY   A549 EGFR SH2 Biosensor
DR   cancercelllines; CVCL_C3ET
DR   Sigma-Aldrich; CLL1097
DR   Wikidata; Q114310513
CC   Population: Caucasian.
CC   Characteristics: Within minutes after stimulation of the cell line with EGF, the biosensor shows robust redistribution towards the cell membrane and subsequent internalization through endocytosis (Sigma-Aldrich=CLL1097).
CC   Characteristics: Transduced with a TagGFP2-SH2-SH2 construct (Sigma-Aldrich=CLL1097).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=FPbase; GJETS; TagGFP2 (Note=Green fluorescent protein derived from Aequorea macrodactyla GFP).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 7
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