ID   WM8
AC   CVCL_C281
SY   WM-8; WM 8
DR   cancercelllines; CVCL_C281
DR   Cosmic; 928683
DR   Cosmic; 1155543
DR   GEO; GSM185206
DR   GEO; GSM185207
DR   GEO; GSM952610
DR   IARC_TP53; 24989
DR   Progenetix; CVCL_C281
DR   Rockland; WM8-01-0001
DR   Wikidata; Q54994319
RX   PubMed=286328;
RX   PubMed=18632627;
WW   Info; Wistar; -; https://www.wistar.org/our-scientists/meenhard-herlyn
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asn822Lys (c.2466T>A) (N818K); ClinVar=VCV000375931; Zygosity=Unspecified (Wistar).
CC   Omics: Transcriptomics; Microarray.
CC   Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D19S433: 12.2,15->15, D8S1179: 11,12,14->12,14 and FGA: 22->22,27.
CC   Derived from site: Metastatic; Not specified.
ST   Source(s): Wistar
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 19,20
ST   D19S433: 15
ST   D21S11: 30
ST   D2S1338: 17,23
ST   D3S1358: 15,16
ST   D5S818: 12,13
ST   D7S820: 9,13
ST   D8S1179: 12,14
ST   FGA: 22,27
ST   TH01: 8
ST   TPOX: 8,11
ST   vWA: 16,19
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-10-12; Last updated: 10-04-25; Version: 22
//
RX   PubMed=286328; DOI=10.1073/pnas.76.3.1438; PMCID=PMC383267;
RA   Herlyn M., Steplewski Z., Herlyn D., Koprowski H.;
RT   "Colorectal carcinoma-specific antigen: detection by means of
RT   monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).
//
RX   PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688;
RA   Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R.,
RA   Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M.,
RA   Nathanson K.L.;
RT   "Identification of a novel subgroup of melanomas with
RT   KIT/cyclin-dependent kinase-4 overexpression.";
RL   Cancer Res. 68:5743-5752(2008).
//