ID   SNU-601 Ola-R
AC   CVCL_C1NB
SY   SNU-601/olaparib-resistant; Olaparib-resistant SNU-601
DR   cancercelllines; CVCL_C1NB
DR   Wikidata; Q114313042
RX   PubMed=32028591;
CC   Population: Korean.
CC   Selected for resistance to: ChEBI; CHEBI_83766; Olaparib.
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:18884; TDP1; Simple; p.Ala520Asp; Zygosity=Unspecified (PubMed=32028591).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C5250; Gastric signet ring cell adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0101 ! SNU-601
SX   Male
AG   34Y
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=32028591; DOI=10.3390/cancers12020334; PMCID=PMC7072281;
RA   Kim, Jin Won
RA   Min, Ahrum
RA   Im, Seock-Ah
RA   Jang, Hyemin
RA   Kim, Yu Jin
RA   Kim, Hee-Jun
RA   Lee, Kyung-Hun
RA   Kim, Tae-Yong
RA   Lee, Keun Wook
RA   Oh, Do-Youn
RA   Kim, Jee-Hyun
RA   Bang, Yung-Jue
RT   "TDP1 and TOP1 modulation in olaparib-resistant cancer determines the
RT   efficacy of subsequent chemotherapy.";
RL   Cancers (Basel) 12:334.1-334.17(2020).
//