ID   HB-2
AC   CVCL_C1LF
SY   HB-second generation
DR   Wikidata; Q114311564
RX   PubMed=20464641;
CC   Characteristics: Increased tumorigenicity compared to the parent cell line. Established from a tumor obtained from inoculation of the parent cell line in nude mice (PubMed=20464641).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Transformant: ChEBI; CHEBI_29865; Benzo[a]pyrene.
CC   Derived from site: In situ; Oral cavity, oral mucosa; UBERON=UBERON_0003729.
CC   Cell type: Epithelial cell; CL=CL_0000066.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6E44 ! HIOEC-B(a)P-96
SX   Female
AG   Age unspecified
CA   Transformed cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 7
//
RX   PubMed=20464641; DOI=10.1007/s12032-010-9558-4;
RA   Ye D.-X., Zhou X.-J., Pan H.-Y., Jiang Q., Zhong L.-P., Chen W.-T.,
RA   Zhang Z.-Y.;
RT   "Establishment and characterization of an HPV16 E6/E7-expressing oral
RT   squamous cell carcinoma cell line with enhanced tumorigenicity.";
RL   Med. Oncol. 28:1331-1337(2011).
//