ID   RPE1_EZH2_A1
AC   CVCL_C1AX
DR   Wikidata; Q114312829
RX   PubMed=35692635;
CC   Part of: Cancer Pathway Knockout Panel.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:3527; EZH2.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Eye, retina, retinal pigment epithelium; UBERON=UBERON_0001782.
CC   Cell type: Retinal pigment epithelial cell; CL=CL_0002586.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4388 ! hTERT-RPE1
SX   Female
AG   1Y
CA   Telomerase immortalized cell line
DT   Created: 22-09-22; Last updated: 19-12-24; Version: 7
//
RX   PubMed=35692635; DOI=10.1016/j.isci.2022.104437; PMCID=PMC9184558;
RA   Cook, Ashley L.
RA   Wyhs, Nicolas
RA   Sur, Surojit
RA   Ptak, Blair
RA   Popoli, Maria
RA   Dobbyn, Laura
RA   Papadopoulos, Tasos
RA   Bettegowda, Chetan
RA   Papadopoulos, Nickolas
RA   Vogelstein, Bert
RA   Zhou, Shi-Bin
RA   Kinzler, Kenneth Wayne
RT   "An isogenic cell line panel for sequence-based screening of targeted
RT   anticancer drugs.";
RL   iScience 25:104437.1-104437.13(2022).
//