ID   ACTOne cAMP-PDE4B
AC   CVCL_C0U3
SY   ACTOne PDE4B; PDE4B ACTOne; CHO-K1-CNG-PDE4B
DR   Wikidata; Q112929139
WW   Provider; Dexorgen; CB-81200-106; https://www.dexorgen.com/actone-cell-lines/
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen).
CC   Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR (Dexorgen).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8781; PDE4B.
CC   Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_C0RV ! CHO-K1-CNG-Gs
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 8
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