ID   ACTOne cAMP-PDE4A
AC   CVCL_C0U2
SY   ACTOne PDE4A; PDE4A ACTOne; CHO-K1-CNG-PDE4A
DR   Wikidata; Q112929138
WW   Provider; Dexorgen; CB-81200-105; https://www.dexorgen.com/actone-cell-lines/
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Dexorgen).
CC   Characteristics: Expresses a constitutively active over-expressed Gs-coupled GPCR (Dexorgen).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:8780; PDE4A.
CC   Genetic integration: Method=Transduction; Gene=RGD; 2367; Cnga2 (Note=With p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_C0RV ! CHO-K1-CNG-Gs
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 8
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