ID   ACTOne TSHR
AC   CVCL_C0TU
DR   Wikidata; Q112929196
RX   PubMed=18216391;
WW   http://www.codexbiosolutions.com/wp-content/uploads/cb-80200-242.pdf
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Codex BioSolutions).
CC   Transfected with: RGD; 2367; Cnga2 (with p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Transfected with: HGNC; 12373; TSHR.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C0RU ! HEK293-CNG
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 29-06-23; Version: 4
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RX   PubMed=18216391; DOI=10.1177/1087057107313786;
RA   Titus S.A., Neumann S., Zheng W., Southall N., Michael S., Klumpp C.,
RA   Yasgar A., Shinn P., Thomas C.J., Inglese J., Gershengorn M.C.,
RA   Austin C.P.;
RT   "Quantitative high-throughput screening using a live-cell cAMP assay
RT   identifies small-molecule agonists of the TSH receptor.";
RL   J. Biomol. Screen. 13:120-127(2008).
//