ID   HEK293-CNG
AC   CVCL_C0RU
SY   HEK-293-CNG; HEK293/CNG; CNG-HEK293; HEK CNG; HEK oCNG-NC-5
DR   Wikidata; Q112929679
RX   PubMed=14555181;
CC   Characteristics: Expresses a modified cyclic nucleotide gated (CNG) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization. Allows sensitive detection of signaling by Gs, Gi or Gq-coupled receptors (Codex BioSolutions).
CC   Characteristics: Parent cell line for many ACTOne cell lines.
CC   Transfected with: RGD; 2367; Cnga2 (with p.Phe68Ala, p.Trp81Ala, p.Cys460Trp and p.Glu583Met = oCNG-NC).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5.
CC   Miscellaneous: Has Codex Biosolutions catalog number CB-81200-200/AG-10200-200, but not distributed separately from children cell lines.
CC   Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0045 ! HEK293
SX   Female
AG   Fetus
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 29-06-23; Version: 4
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RX   PubMed=14555181; DOI=10.1016/j.ejphar.2003.08.036;
RA   Reinscheid R.K., Kim J., Zeng J., Civelli O.;
RT   "High-throughput real-time monitoring of Gs-coupled receptor
RT   activation in intact cells using cyclic nucleotide-gated channels.";
RL   Eur. J. Pharmacol. 478:27-34(2003).
//