ID   A375M1
AC   CVCL_C0RN
DR   cancercelllines; CVCL_C0RN
DR   Wikidata; Q112927060
RX   PubMed=10952316;
CC   Population: Caucasian.
CC   Characteristics: Metastatic. Established from pulmonary metastases obtained afer intravenous injection of the parent cell line into the tail veins of nude mice.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6233 ! A375-P
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
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RX   PubMed=10952316; DOI=10.1038/35020106;
RA   Clark E.A., Golub T.R., Lander E.S., Hynes R.O.;
RT   "Genomic analysis of metastasis reveals an essential role for RhoC.";
RL   Nature 406:532-535(2000).
//