ID   HUDEP2 HBB-KO
AC   CVCL_C0QM
DR   PRIDE; PXD030182
DR   Wikidata; Q112929794
RX   PubMed=35269949;
CC   Population: Japanese.
CC   Characteristics: Expression of the HPV16 E6 and E7 genes is induced by tetracycline (from parent cell line).
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:4827; HBB.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Genomics; Chromatin accessibility; ATAC-seq.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Umbilical cord blood; UBERON=UBERON_0012168.
CC   Cell type: Erythroid progenitor cell; CL=CL_0000038.
DI   NCIt; C34383; Sickle cell disease
DI   ORDO; Orphanet_232; Sickle cell anemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_VI06 ! HUDEP-2
SX   Sex unspecified
AG   <1D
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 8
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RX   PubMed=35269949; DOI=10.3390/ijms23052807; PMCID=PMC8911073;
RA   Zhou G.-Q., Zhang H.-K., Lin A.-N., Wu Z., Li T., Zhang X.-M.,
RA   Chen H.-Y., Lu D.-R.;
RT   "Multi-omics analysis in beta-thalassemia using an HBB gene-knockout
RT   human erythroid progenitor cell model.";
RL   Int. J. Mol. Sci. 23:2807.1-2807.14(2022).
//