ID   HEL 92.1.7 SOD2 KO clone 5
AC   CVCL_C0D0
SY   HEL SOD2-/- clone 5; SOD2-/- HEL clone 5; SOD2-/- cl.5
DR   cancercelllines; CVCL_C0D0
DR   Wikidata; Q112929701
RX   PubMed=33585836;
CC   Population: Caucasian.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11180; SOD2.
CC   Sequence variation: Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Lys (c.398T>A); ClinVar=VCV002430159; Zygosity=Homozygous (from parent cell line).
CC   Donor information: Originally the patient was suffering from Hodgkin lymphoma.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C7152; Erythroleukemia
DI   ORDO; Orphanet_318; Acute erythroid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2481 ! HEL 92.1.7
SX   Male
AG   30Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 19-12-24; Version: 7
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RX   PubMed=33585836; DOI=10.33696/pathology.1.009; PMCID=PMC7876477;
RA   Cramer-Morales K.L., Heer C.D., Mapuskar K.A., Domann F.E.;
RT   "Succinate accumulation links mitochondrial MnSOD depletion to
RT   aberrant nuclear DNA methylation and altered cell fate.";
RL   J. Exp. Pathol. (Wilmington) 1:60-70(2020).
//