ID   UPCI-SCC-036
AC   CVCL_C030
SY   UPCI:SCC036; SCC036
DR   cancercelllines; CVCL_C030
DR   DSMZ; ACC-865
DR   DSMZCellDive; ACC-865
DR   GEO; GSM937838
DR   GEO; GSM937839
DR   IARC_TP53; 18353
DR   Wikidata; Q54991573
RX   PubMed=12872257;
RX   PubMed=17112776;
RX   PubMed=17681875;
RX   PubMed=23419152;
RX   PubMed=24403267;
CC   Population: Caucasian.
CC   Virology: The tumor is positive to HPV (PubMed=17112776), but the cell line is HPV negative (PubMed=23419152; PubMed=24403267).
CC   Doubling time: ~48 hours (DSMZ=ACC-865).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ile195Phe (c.583A>T); ClinVar=VCV000376617; Zygosity=Unspecified (PubMed=12872257).
CC   Omics: Genomics; DNA methylation analysis.
CC   Derived from site: In situ; Oral cavity, tonsil; UBERON=UBERON_0002372.
ST   Source(s): DSMZ=ACC-865
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11,13
ST   D16S539: 11,12
ST   D18S51: 17
ST   D19S433: 13
ST   D21S11: 29,30
ST   D2S1338: 22,25
ST   D3S1358: 18
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   D8S1179: 13,14
ST   FGA: 20
ST   Penta D: 9
ST   Penta E: 11
ST   TH01: 6,9
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C8183; Tonsillar squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C050 ! UPCI-SCC-104
OI   CVCL_C056 ! UPCI-SCC-142
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 19
//
RX   PubMed=12872257; DOI=10.1002/humu.10248;
RA   Telmer C.A., An J.-Y., Malehorn D.E., Zeng X.-M., Gollin S.M.,
RA   Ishwad C.S., Jarvik J.W.;
RT   "Detection and assignment of TP53 mutations in tumor DNA using peptide
RT   mass signature genotyping.";
RL   Hum. Mutat. 22:158-165(2003).
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692;
RA   White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L.,
RA   Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T.,
RA   Gollin S.M.;
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=17681875; DOI=10.1016/j.oraloncology.2007.05.003; PMCID=PMC2362065;
RA   Martin C.L., Reshmi S.C., Ried T., Gottberg W., Wilson J.W.,
RA   Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.;
RT   "Chromosomal imbalances in oral squamous cell carcinoma: examination
RT   of 31 cell lines and review of the literature.";
RL   Oral Oncol. 44:369-382(2008).
//
RX   PubMed=23419152; DOI=10.1186/gm419; PMCID=PMC3706778;
RA   Lechner M., Fenton T., West J., Wilson G., Feber A., Henderson S.,
RA   Thirlwell C., Dibra H.K., Jay A., Butcher L.M., Chakravarthy A.R.,
RA   Gratrix F., Patel N., Vaz F., O'Flynn P., Kalavrezos N.,
RA   Teschendorff A.E., Boshoff C., Beck S.;
RT   "Identification and functional validation of HPV-mediated
RT   hypermethylation in head and neck squamous cell carcinoma.";
RL   Genome Med. 5:15.1-15.16(2013).
//
RX   PubMed=24403267; DOI=10.1002/cam4.151; PMCID=PMC3892398;
RA   Kawakami H., Okamoto I., Terao K., Sakai K., Suzuki M., Ueda S.,
RA   Tanaka K., Kuwata K., Morita Y., Ono K., Nishio K., Nishimura Y.,
RA   Doi K., Nakagawa K.;
RT   "Human papillomavirus DNA and p16 expression in Japanese patients with
RT   oropharyngeal squamous cell carcinoma.";
RL   Cancer Med. 2:933-941(2013).
//