ID   UBT-5
AC   CVCL_B972
DR   Wikidata; Q54973900
RX   PubMed=15293342;
RX   PubMed=15923633;
CC   Population: Japanese and Korean.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1066; BMI1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mesenchymal stem cell of bone marrow; CL=CL_0002540.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6F32 ! H4-1 [Human bone marrow]
SX   Female
AG   91Y
CA   Telomerase immortalized cell line
DT   Created: 06-06-12; Last updated: 19-12-24; Version: 12
//
RX   PubMed=15293342; DOI=10.1002/jgm.583;
RA   Takeda Y., Mori T., Imabayashi H., Kiyono T., Gojo S., Miyoshi S.,
RA   Hida N., Ita M., Segawa K., Ogawa S., Sakamoto M., Nakamura S.,
RA   Umezawa A.;
RT   "Can the life span of human marrow stromal cells be prolonged by bmi-1,
RT   E6, E7, and/or telomerase without affecting cardiomyogenic
RT   differentiation?";
RL   J. Gene Med. 6:833-845(2004).
//
RX   PubMed=15923633; DOI=10.1128/mcb.25.12.5183-5195.2005; PMCID=PMC1140572;
RA   Mori T., Kiyono T., Imabayashi H., Takeda Y., Tsuchiya K., Miyoshi S.,
RA   Makino H., Matsumoto K., Saito H., Ogawa S., Sakamoto M., Hata J.-i.,
RA   Umezawa A.;
RT   "Combination of hTERT and bmi-1, E6, or E7 induces prolongation of the
RT   life span of bone marrow stromal cells from an elderly donor without
RT   affecting their neurogenic potential.";
RL   Mol. Cell. Biol. 25:5183-5195(2005).
//