ID   e-hChon-1
AC   CVCL_B7TU
DR   Wikidata; Q112929466
RX   PubMed=29520052;
CC   Characteristics: Transduced with a lentiviral library consisting of 33 genes, some of which are retained in the immortalized cell line (CI-SCREEN) (PubMed=29520052).
CC   Karyotypic information: 46<2n>XX,del(2)(q3?),-4,add(7)(p14),+21,add(22)(q13) (PubMed=29520052).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3527; EZH2.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:3796; FOS.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5360; ID1.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5361; ID2.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5362; ID3.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:6348; KLF4.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:7553; MYC.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:88174; Bmi1.
CC   Genetic integration: Method=Transduction; Gene=MGI; MGI:1919200; Nanog.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03077; Murine polyomavirus (strain A2) (MPyV) middle T antigen (PyMT).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=Hepatitis C virus core protein.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Transformant: NCBI_TaxID; 1891730; Murine polyomavirus (MPyV).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Femoral head, cartilage; UBERON=UBERON_8480062.
CC   Cell type: Chondrocyte; CL=CL_0000138.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B7TV ! e-hChon-2
OI   CVCL_B7TW ! e-hChon-3
OI   CVCL_B7TX ! e-hChon-4
SX   Female
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 8
//
RX   PubMed=29520052; DOI=10.1038/s41467-018-03408-4; PMCID=PMC5843645;
RA   Lipps C., Klein F., Wahlicht T., Seiffert V., Butueva M., Zauers J.,
RA   Truschel T., Luckner M., Koster M., MacLeod R.A.F., Pezoldt J., Huhn J.,
RA   Yuan Q.-G., Muller P.P., Kempf H., Zweigerdt R., Dittrich-Breiholz O.,
RA   Pufe T., Beckmann R., Drescher W., Riancho J.A., Sanudo C., Korff T.,
RA   Opalka B., Rebmann V., Gothert J.R., Alves P.M., Ott M., Schucht R.,
RA   Hauser H., Wirth D., May T.;
RT   "Expansion of functional personalized cells with specific transgene
RT   combinations.";
RL   Nat. Commun. 9:994.1-994.12(2018).
//