ID   SRD-5
AC   CVCL_B7PG
SY   Sterol Regulatory Defective-5
DR   Wikidata; Q112930423
RX   PubMed=12482938;
CC   Selected for resistance to: ChEBI; CHEBI_42977; 25-hydroxycholesterol.
CC   Sequence variation: Mutation; UniProtKB; P97260; Scap; Simple; p.Leu315Phe (c.943C>T); Zygosity=Heterozygous (PubMed=12482938).
CC   Transformant: ChEBI; CHEBI_23995; N-ethyl-N-nitrosourea (ENU).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_D893 ! CHO-7
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 23-06-22; Last updated: 19-12-24; Version: 6
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RX   PubMed=12482938; DOI=10.1073/pnas.262669399; PMCID=PMC139202;
RA   Yabe D., Xia Z.-P., Adams C.M., Rawson R.B.;
RT   "Three mutations in sterol-sensing domain of SCAP block interaction
RT   with insig and render SREBP cleavage insensitive to sterols.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16672-16677(2002).
//