ID   mCCDcl1
AC   CVCL_B7HR
SY   mCCD(cl1); mCCD-CL1; mCCD cl1; mouse Cortical Collecting Duct clone 1
DR   ABM; T0620
DR   Wikidata; Q112930084
RX   PubMed=15743993;
RX   PubMed=19297448;
RX   PubMed=21178974;
RX   PubMed=29357433;
CC   Characteristics: Expresses epithelial sodium channels (ENaC) as well as the necessary cellular machinery to enable their stimulation by physiological concentrations of aldosterone, including 11-betahydroxysteroid dehydrogenase (HSD11b2), mineralocorticoid and glucocorticoid receptors and have therefore been used as a model for the study of principal cells physiology (PubMed=15743993; PubMed=29357433).
CC   Doubling time: ~24 hours (Direct_author_submission).
CC   Omics: Transcriptomics; RNAseq.
CC   Miscellaneous: Doubling time from personal communication of Rossier, Bernard Claude.
CC   Miscellaneous: Sex of mouse and STR profile from personal communication of Hummler, Edith.
CC   Derived from site: In situ; Kidney, cortical collecting duct; UBERON=UBERON_0004203.
CC   Cell type: Kidney collecting duct principal cell; CL=CL_1001431.
ST   Source(s): ABM=T0620; Direct_author_submission
ST   Mouse STR 1-1: 16
ST   Mouse STR 1-2: 19,20
ST   Mouse STR 2-1: 16
ST   Mouse STR 3-2: 14
ST   Mouse STR 4-2: 20.3
ST   Mouse STR 5-5: 13,14
ST   Mouse STR 6-4: 17.3 (Direct_author_submission)
ST   Mouse STR 6-4: 18 (ABM=T0620)
ST   Mouse STR 6-7: 17
ST   Mouse STR 7-1: 26.2,27.2,31
ST   Mouse STR 8-1: 16
ST   Mouse STR 11-2: 17
ST   Mouse STR 12-1: 17
ST   Mouse STR 13-1: 17
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 17-2: 15,17
ST   Mouse STR 18-3: 16
ST   Mouse STR 19-2: 12,13
ST   Mouse STR X-1: 28
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Male
AG   Age unspecified
CA   Spontaneously immortalized cell line
DT   Created: 23-06-22; Last updated: 10-04-25; Version: 6
//
RX   PubMed=15743993; DOI=10.1681/ASN.2004121110;
RA   Gaeggeler H.-P., Gonzalez-Rodriguez E., Fowler-Jaeger N., Loffing-Cueni D.,
RA   Norregaard R., Loffing J., Horisberger J.-D., Rossier B.C.;
RT   "Mineralocorticoid versus glucocorticoid receptor occupancy mediating
RT   aldosterone-stimulated sodium transport in a novel renal cell line.";
RL   J. Am. Soc. Nephrol. 16:878-891(2005).
//
RX   PubMed=19297448; DOI=10.1152/ajprenal.90475.2008;
RA   Fodstad H., Gonzalez-Rodriguez E., Bron S., Gaeggeler H.-P., Guisan B.,
RA   Rossier B.C., Horisberger J.-D.;
RT   "Effects of mineralocorticoid and K+ concentration on K+ secretion and
RT   ROMK channel expression in a mouse cortical collecting duct cell
RT   line.";
RL   Am. J. Physiol. Renal Physiol. 296:F966-F975(2009).
//
RX   PubMed=21178974; DOI=10.1038/ki.2010.486;
RA   Gaeggeler H.-P., Guillod Y., Loffing-Cueni D., Loffing J.,
RA   Rossier B.C.;
RT   "Vasopressin-dependent coupling between sodium transport and water
RT   flow in a mouse cortical collecting duct cell line.";
RL   Kidney Int. 79:843-852(2011).
//
RX   PubMed=29357433; DOI=10.1152/ajprenal.00354.2017;
RA   Assmus A.M., Mansley M.K., Mullins L.J., Peter A., Mullins J.J.;
RT   "mCCDcl1 cells show plasticity consistent with the ability to
RT   transition between principal and intercalated cells.";
RL   Am. J. Physiol. Renal Physiol. 314:F820-F831(2018).
//