ID   Mel Il
AC   CVCL_B6KD
SY   mel Il; Mel IL; mel IL
DR   cancercelllines; CVCL_B6KD
DR   Wikidata; Q112129273
RX   CelloPub=CLPUB00680;
RX   CelloPub=CLPUB00681;
RX   Patent=RU2287577;
RX   PubMed=18781128;
RX   PubMed=28881731;
RX   PubMed=30551515;
CC   Group: Patented cell line.
CC   Registration: Non-internationally recognized Depositary Authority, Russian Cell Culture Collection (RCCC); 686D.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Lys (c.1798_1799delGTinsAA); ClinVar=VCV000375941; Zygosity=Unspecified (CelloPub=CLPUB00680; PubMed=28881731; PubMed=30551515).
CC   Derived from site: Metastatic; Chest, hypodermis; UBERON=UBERON_0001443+UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 05-10-23; Version: 5
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RX   CelloPub=CLPUB00680;
RA   Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S.,
RA   Shubina I.Z., Kovalevsky D.A., Voronina E.S., Treshalina H.M.,
RA   Lushnikova A.A., Tsyganova I.V., Mazurenko N.N.;
RT   "Human skin melanoma cell lines collection.";
RL   (In) Management of malignant melanoma; None X. (eds.); pp.6.1-6.6; SM Group; Dover (2016).
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RX   CelloPub=CLPUB00681;
RA   Berezhnoy A.E., Zakeyeva I.R., Kibardin A.V., Chernysheva A.D.,
RA   Moiseyenko V.M., Danilov A.O., Demidov L.V., Baryshnikov A.Y.,
RA   Gnuchev N.V., Georgiev G.P., Larin S.S.;
RT   "Analysis of HLA-E expression in human melanoma cells.";
RL   Ross. Bioterap. Zh. 5:66-71(2006).
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RX   Patent=RU2287577;
RA   Mikhailova I.N., Baryshnikov A.Y., Morozova L.F., Burova O.S.,
RA   Demidov L.V., Lukashina M.I., Larin S.S., Georgiev G.P.,
RA   Vorozhtsov G.N., Gnuchev N.V.;
RT   "Human melanoma cellular line mel IL used in preparing antitumor
RT   vaccine.";
RL   Patent number RU2287577, 20-Nov-2006.
//
RX   PubMed=18781128; DOI=10.1097/CMR.0b013e32830e391d;
RA   Mikhailova I.N., Kovalevsky D.A., Morozova L.F., Golubeva V.A.,
RA   Cheremushkin E.A., Lukashina M.I., Voronina E.S., Burova O.S.,
RA   Utyashev I.A., Kiselev S.L., Demidov L.V., Beabealashvilli R.S.,
RA   Baryshnikov A.Y.;
RT   "Cancer/testis genes expression in human melanoma cell lines.";
RL   Melanoma Res. 18:303-313(2008).
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RX   PubMed=28881731; DOI=10.18632/oncotarget.17014;
RA   Emelyanova M., Ghukasyan L., Abramov I., Ryabaya O., Stepanova E.V.,
RA   Kudryavtseva A., Sadritdinova A., Dzhumakova C., Belysheva T.,
RA   Surzhikov S., Lyubchenko L., Zasedatelev A., Nasedkina T.;
RT   "Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in
RT   Russian melanoma patients using LNA PCR clamp and biochip analysis.";
RL   Oncotarget 8:52304-52320(2017).
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RX   PubMed=30551515; DOI=10.1016/j.biopha.2018.11.109;
RA   Ryabaya O., Prokofieva A., Akasov R., Khochenkov D., Emelyanova M.,
RA   Burov S., Markvicheva E., Inshakov A., Stepanova E.V.;
RT   "Metformin increases antitumor activity of MEK inhibitor binimetinib
RT   in 2D and 3D models of human metastatic melanoma cells.";
RL   Biomed. Pharmacother. 109:2548-2560(2019).
//