ID   IM-9-P
AC   CVCL_B6CV
DR   Wikidata; Q111733497
RX   PubMed=1366653;
RX   PubMed=1697858;
RX   PubMed=2836165;
CC   Problematic cell line: Misclassified. Parent cell line originally thought to be a myeloma cell line but is a B-lymphoblastoid cell line.
CC   Population: Caucasian.
CC   Characteristics: Produces prolactin. But after approximately 7 months in culture the capacity to synthesize prolactin is greatly reduced (PubMed=1366653; PubMed=2836165).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1305 ! IM-9
SX   Female
AG   Age unspecified
CA   Transformed cell line
DT   Created: 17-03-22; Last updated: 19-12-24; Version: 5
CH   CVCL_B6CW ! IM-9-P3
CH   CVCL_B6CX ! IM-9-P6
//
RX   PubMed=1366653; DOI=10.1007/BF00365265;
RA   Bonhoff, Annette
RA   Gellersen, Birgit
RA   Held, Karsten R.
RA   Bohnet, Heinz G.
RT   "Clonal derivatives of a human B-lymphoblastoid cell line producing
RT   prolactin -- a cytogenetic characterization.";
RL   Cytotechnology 3:43-50(1990).
//
RX   PubMed=1697858; DOI=10.1016/S0021-9258(17)46238-7;
RA   DiMattia, Gabriel E.
RA   Gellersen, Birgit
RA   Duckworth, Mary Lynn
RA   Friesen, Henry George
RT   "Human prolactin gene expression. The use of an alternative noncoding
RT   exon in decidua and the IM-9-P3 lymphoblast cell line.";
RL   J. Biol. Chem. 265:16412-16421(1990).
//
RX   PubMed=2836165; DOI=10.1210/endo-122-6-2508;
RA   DiMattia, Gabriel E.
RA   Gellersen, Birgit
RA   Bohnet, Heinz G.
RA   Friesen, Henry George
RT   "A human B-lymphoblastoid cell line produces prolactin.";
RL   Endocrinology 122:2508-2517(1988).
//