ID   HAP1 RAB1A (-) 2
AC   CVCL_B5KT
SY   HZGHC007227c012; RAB1A knockout cell line 1bp deletion in exon 4
DR   cancercelllines; CVCL_B5KT
DR   Horizon_Discovery; HZGHC007227c012
DR   Wikidata; Q111733315
RX   PubMed=38559361;
CC   Group: Haploid karyotype cell line.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:9758; RAB1A.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_Y019 ! HAP1
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 17-03-22; Last updated: 10-04-25; Version: 8
//
RX   PubMed=38559361; DOI=10.12688/f1000research.143928.2; PMCID=PMC10979127;
RA   Ruiz Moleon V., Fotouhi M., Ayoubi R., Gonzalez Bolivar S., Southern K.,
RA   McPherson P.S., Laflamme C.;
RG   ABIF Consortium;
RG   NeuroSGC/YCharOS/EDDU Collaborative Group;
RT   "A guide to selecting high-performing antibodies for Rab1A and Rab1B
RT   for use in western blot, immunoprecipitation and immunofluorescence.";
RL   F1000Research 12:1578.1-1578.13(2023).
//