ID   Twin-N
AC   CVCL_B4L2
SY   T2N
DR   GEO; GSE123028
DR   GEO; GSE135500
DR   GEO; GSM1338309
DR   GEO; GSM1338310
DR   GEO; GSM1338344
DR   GEO; GSM1338342
DR   GEO; GSM1338312
DR   GEO; GSM1338314
DR   GEO; GSM1338316
DR   GEO; GSM1338318
DR   GEO; GSM1333658
DR   GEO; GSM1333660
DR   PRIDE; PXD004880
DR   Wikidata; Q110433294
RX   PubMed=24375627;
RX   PubMed=24740065;
RX   PubMed=25557783;
RX   PubMed=28190458;
RX   PubMed=30510006;
RX   PubMed=32739879;
CC   From: University of Geneva; Geneva; Switzerland.
CC   Population: Caucasian.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: Deep proteome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Transcriptome analysis by single cell RNAseq.
CC   Donor information: Twin-DS (Cellosaurus=CVCL_B4L1) and Twin-N originate from monozygotic twins discordant for trisomy 21.
CC   Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003399.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   16FW
CA   Finite cell line
DT   Created: 16-12-21; Last updated: 29-06-23; Version: 5
//
RX   PubMed=24375627; DOI=10.1002/emmm.201302848;
RA   Hibaoui Y., Grad I., Letourneau A., Sailani M.R., Dahoun S.,
RA   Santoni F.A., Gimelli S., Guipponi M., Pelte M.-F., Sloan-Bena F.,
RA   Antonarakis S.E., Feki A.;
RT   "Modelling and rescuing neurodevelopmental defect of Down syndrome
RT   using induced pluripotent stem cells from monozygotic twins discordant
RT   for trisomy 21.";
RL   EMBO Mol. Med. 6:259-277(2014).
//
RX   PubMed=24740065; DOI=10.1038/nature13200;
RA   Letourneau A., Santoni F.A., Bonilla X., Sailani M.R., Gonzalez D.,
RA   Kind J., Chevalier C., Thurman R., Sandstrom R.S., Hibaoui Y.,
RA   Garieri M., Popadin K.Y., Falconnet E., Gagnebin M., Gehrig C.,
RA   Vannier A., Guipponi M., Farinelli L., Robyr D., Migliavacca E.,
RA   Borel C., Deutsch S., Feki A., Stamatoyannopoulos J.A., Herault Y.,
RA   van Steensel B., Guigo R., Antonarakis S.E.;
RT   "Domains of genome-wide gene expression dysregulation in Down's
RT   syndrome.";
RL   Nature 508:345-350(2014).
//
RX   PubMed=25557783; DOI=10.1016/j.ajhg.2014.12.001;
RA   Borel C., Ferreira P.G., Santoni F.A., Delaneau O., Fort A.,
RA   Popadin K.Y., Garieri M., Falconnet E., Ribaux P., Guipponi M.,
RA   Padioleau I., Carninci P., Dermitzakis E.T., Antonarakis S.E.;
RT   "Biased allelic expression in human primary fibroblast single cells.";
RL   Am. J. Hum. Genet. 96:70-80(2015).
//
RX   PubMed=28190458; DOI=10.1016/j.ajhg.2017.01.028;
RA   Santoni F.A., Stamoulis G., Garieri M., Falconnet E., Ribaux P.,
RA   Borel C., Antonarakis S.E.;
RT   "Detection of imprinted genes by single-cell allele-specific gene
RT   expression.";
RL   Am. J. Hum. Genet. 100:444-453(2017).
//
RX   PubMed=30510006; DOI=10.1073/pnas.1806811115;
RA   Garieri M., Stamoulis G., Blanc X., Falconnet E., Ribaux P., Borel C.,
RA   Santoni F.A., Antonarakis S.E.;
RT   "Extensive cellular heterogeneity of X inactivation revealed by
RT   single-cell allele-specific expression in human fibroblasts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:13015-13020(2018).
//
RX   PubMed=32739879; DOI=10.1016/j.scr.2020.101920;
RA   Feki A., Sloan-Bena F., Hibaoui Y.;
RT   "Parallel derivation of X-monosomy induced pluripotent stem cells
RT   (iPSCs) with isogenic control iPSCs.";
RL   Stem Cell Res. 47:101920-101920(2020).
//