ID   SU-CCS-1
AC   CVCL_B470
SY   Su-ccs-1; Su CCS-1; SU-CCS1; SUCCS1
DR   ATCC; CRL-2971
DR   Cosmic; 1092866
DR   EGA; EGAD00001008611
DR   Wikidata; Q54970704
RX   PubMed=6362860;
RX   PubMed=7753552;
RX   PubMed=12966428;
RX   PubMed=15150091;
RX   PubMed=16766266;
RX   PubMed=28745431;
RX   PubMed=36959380;
CC   Population: Caucasian.
CC   Doubling time: ~52 hours (PubMed=6362860).
CC   Sequence variation: Gene fusion; HGNC; HGNC:783; ATF1 + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ATF1, EWS-ATF; Note=Type 1: EWSR1 exon 8 fused to ATF1 exon 4 (PubMed=7753552; PubMed=15150091; PubMed=28745431).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ATCC=CRL-2971; PubMed=36959380
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8
ST   D16S539: 11
ST   D18S51: 12,16
ST   D19S433: 12,14
ST   D21S11: 28,30
ST   D2S1338: 16,20
ST   D3S1358: 15,18
ST   D5S818: 12,14
ST   D7S820: 12
ST   D8S1179: 10
ST   FGA: 22.2,24
ST   Penta D: 9,12
ST   Penta E: 12
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3745; Clear cell sarcoma of soft tissue
DI   ORDO; Orphanet_3394; Soft tissue sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   16Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
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RX   PubMed=6362860;
RA   Epstein A.L., Martin A.O., Kempson R.;
RT   "Use of a newly established human cell line (SU-CCS-1) to demonstrate
RT   the relationship of clear cell sarcoma to malignant melanoma.";
RL   Cancer Res. 44:1265-1274(1984).
//
RX   PubMed=7753552;
RA   Brown A.D., Lopez-Terrada D.H., Denny C.T., Lee K.A.W.;
RT   "Promoters containing ATF-binding sites are de-regulated in cells that
RT   express the EWS/ATF1 oncogene.";
RL   Oncogene 10:1749-1756(1995).
//
RX   PubMed=12966428; DOI=10.1038/sj.bjc.6601212; PMCID=PMC2376962;
RA   Li K.K.C., Goodall J., Goding C.R., Liao S.-K., Wang C.-H., Lin Y.-C.,
RA   Hiraga H., Nojima T., Nagashima K., Schaefer K.-L., Lee K.A.W.;
RT   "The melanocyte inducing factor MITF is stably expressed in cell lines
RT   from human clear cell sarcoma.";
RL   Br. J. Cancer 89:1072-1078(2003).
//
RX   PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809;
RA   Schaefer K.-L., Brachwitz K., Wai D.H., Braun Y., Diallo R.,
RA   Korsching E., Eisenacher M., Voss R., van Valen F., Baer C., Selle B.,
RA   Spahn L., Liao S.-K., Lee K.A.W., Hogendoorn P.C.W., Reifenberger G.,
RA   Gabbert H.E., Poremba C.;
RT   "Expression profiling of t(12;22) positive clear cell sarcoma of soft
RT   tissue cell lines reveals characteristic up-regulation of potential
RT   new marker genes including ERBB3.";
RL   Cancer Res. 64:3395-3405(2004).
//
RX   PubMed=16766266; DOI=10.1016/j.ccr.2006.04.021;
RA   Davis I.J., Kim J.J., Ozsolak F., Widlund H.R., Rozenblatt-Rosen O.,
RA   Granter S.R., Du J.-Y., Fletcher J.A., Denny C.T., Lessnick S.L.,
RA   Linehan W.M., Kung A.L.-J., Fisher D.E.;
RT   "Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT
RT   family of human cancers.";
RL   Cancer Cell 9:473-484(2006).
//
RX   PubMed=28745431; DOI=10.1002/cam4.1130; PMCID=PMC5603837;
RA   Nakai T., Imura Y., Tamiya H., Yamada S., Nakai S., Yasuda N., Kaneko K.,
RA   Outani H., Takenaka S., Hamada K., Myoui A., Araki N., Ueda T., Itoh K.,
RA   Yoshikawa H., Naka N.;
RT   "Trabectedin is a promising antitumor agent potentially inducing
RT   melanocytic differentiation for clear cell sarcoma.";
RL   Cancer Med. 6:2121-2130(2017).
//
RX   PubMed=36959380; DOI=10.1038/s41416-023-02222-0; PMCID=PMC10147623;
RA   Rasmussen S.V., Wozniak A., Lathara M., Goldenberg J.M., Samudio B.M.,
RA   Bickford L.R., Nagamori K., Wright H., Woods A.D., Chauhan S., Lee C.-J.,
RA   Rudzinski E.R., Swift M.K., Kondo T., Fisher D.E., Imyanitov E.N.,
RA   Machado I., Llombart-Bosch A., Andrulis I.L., Gokgoz N., Wunder J.S.,
RA   Moritake H., Nakamura T., Srinivasa G., Thway K., Jones R.L., Huang P.H.,
RA   Berlow N.E., Schoffski P., Keller C.;
RT   "Functional genomics of human clear cell sarcoma: genomic,
RT   transcriptomic and chemical biology landscape for clear cell sarcoma.";
RL   Br. J. Cancer 128:1941-1954(2023).
//