ID   OHS
AC   CVCL_B450
SY   OHSX; OHS/X; OHS-50; OHS-50T
DR   cancercelllines; CVCL_B450
DR   Cosmic; 1529909
DR   GEO; GSM879220
DR   GEO; GSM1676308
DR   GEO; GSM1701642
DR   IARC_TP53; 2149
DR   Progenetix; CVCL_B450
DR   Wikidata; Q38098672
RX   PubMed=2233717;
RX   PubMed=3459716;
RX   PubMed=8198963;
RX   PubMed=19787792;
RX   PubMed=21519327;
RX   PubMed=23144859;
RX   PubMed=26351324;
CC   Population: Caucasian.
CC   Doubling time: ~36 hours (PubMed=21519327).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu286Lys (c.856G>A); ClinVar=VCV000183752; Zygosity=Unspecified (PubMed=19787792).
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: In situ; Bone, distal femur; UBERON=UBERON_0004406.
ST   Source(s): PubMed=19787792
ST   Amelogenin: X
ST   D16S539: 12
ST   D18S51: 12,14
ST   D19S433: 14,15
ST   D21S11: 30
ST   D2S1338: 24,25
ST   D3S1358: 16,19
ST   D5S818: 10
ST   D8S1179: 13
ST   FGA: 20,22
ST   SE33: 26.2
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 10-04-25; Version: 18
//
RX   PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990; PMCID=PMC361354;
RA   Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M.,
RA   Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.;
RT   "p53 functions as a cell cycle control protein in osteosarcomas.";
RL   Mol. Cell. Biol. 10:5772-5781(1990).
//
RX   PubMed=3459716; DOI=10.1002/ijc.2910380107;
RA   Fodstad O., Brogger A., Bruland O.S., Solheim O.P., Nesland J.M.,
RA   Pihl A.;
RT   "Characteristics of a cell line established from a patient with
RT   multiple osteosarcoma, appearing 13 years after treatment for
RT   bilateral retinoblastoma.";
RL   Int. J. Cancer 38:33-40(1986).
//
RX   PubMed=8198963; DOI=10.1038/bjc.1994.200; PMCID=PMC1969443;
RA   Kjonniksen I., Rye P.D., Fodstad O.;
RT   "Helix pomatia agglutinin binding in human tumour cell lines:
RT   correlation with pulmonary metastases in nude mice.";
RL   Br. J. Cancer 69:1021-1024(1994).
//
RX   PubMed=19787792; DOI=10.1002/gcc.20717;
RA   Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S.E.,
RA   Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H.,
RA   Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W.,
RA   Buerger H., Aigner T., Gabbert H.E., Poremba C.;
RT   "Molecular characterization of commonly used cell lines for bone tumor
RT   research: a trans-European EuroBoNet effort.";
RL   Genes Chromosomes Cancer 49:40-51(2010).
//
RX   PubMed=21519327; DOI=10.1038/labinvest.2011.72;
RA   Mohseny A.B., Machado I., Cai Y.-P., Schaefer K.-L., Serra M.,
RA   Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.;
RT   "Functional characterization of osteosarcoma cell lines provides
RT   representative models to study the human disease.";
RL   Lab. Invest. 91:1195-1205(2011).
//
RX   PubMed=23144859; DOI=10.1371/journal.pone.0048262; PMCID=PMC3492335;
RA   Kresse S.H., Rydbeck H., Skarn M., Namlos H.M., Barragan-Polania A.H.,
RA   Cleton-Jansen A.-M., Serra M., Liestol K., Hogendoorn P.C.W., Hovig E.,
RA   Myklebost O., Meza-Zepeda L.A.;
RT   "Integrative analysis reveals relationships of genetic and epigenetic
RT   alterations in osteosarcoma.";
RL   PLoS ONE 7:e48262.1-e48262.20(2012).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher B.A., Polley E.C., Kunkel M.W., Evans D., Silvers T.E.,
RA   Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J.,
RA   Harris E., Monks A., Morris J.;
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//