ID   NCC-CCS1B-X2-C1
AC   CVCL_B3TT
SY   NCCCCS1BX2C1
DR   DepMap; ACH-002791
DR   EGA; EGAD00001008611
DR   Wikidata; Q110433082
RX   PubMed=29197033;
RX   PubMed=36959380;
WW   Provider; BizCom; -; https://en.cellline.jp/product/ncc-ccs1b-x2-c1/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: NCC sarcoma cell line panel.
CC   Population: Japanese.
CC   Characteristics: Established from a second generation xenograft established by subcutaneous injection in female NOD/Shi-scid IL-2Rgammanull mice.
CC   Senescence: It is possible that this cell line is not immortal and has a finite life span (personal communication of Kondo, Tadashi).
CC   Doubling time: 20 hours (PubMed=29197033).
CC   Sequence variation: Gene fusion; HGNC; HGNC:783; ATF1 + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ATF1, EWS-ATF (PubMed=29197033).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Left thigh, hypodermis; UBERON=UBERON_0000376+UBERON_0002072.
ST   Source(s): PubMed=29197033; PubMed=36959380
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 8
ST   D16S539: 11
ST   D18S51: 16,19
ST   D21S11: 30,31
ST   D3S1358: 17
ST   D5S818: 11
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 23
ST   Penta D: 9,12
ST   Penta E: 12,19
ST   TH01: 6
ST   TPOX: 11
ST   vWA: 15,16
DI   NCIt; C3745; Clear cell sarcoma of soft tissue
DI   ORDO; Orphanet_3394; Soft tissue sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B3TR ! NCC-CCS1-X4-C1
OI   CVCL_B3TS ! NCC-CCS1B-C1
SX   Female
AG   43Y
CA   Cancer cell line
DT   Created: 16-12-21; Last updated: 10-04-25; Version: 8
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RX   PubMed=29197033; DOI=10.1007/s11626-017-0207-5;
RA   Sakumoto M., Oyama R., Takahashi M., Takai Y., Kito F., Shiozawa K.,
RA   Qiao Z.-W., Endo M., Yoshida A., Kawai A., Kondo T.;
RT   "Establishment and proteomic characterization of patient-derived clear
RT   cell sarcoma xenografts and cell lines.";
RL   In Vitro Cell. Dev. Biol. Anim. 54:163-176(2018).
//
RX   PubMed=36959380; DOI=10.1038/s41416-023-02222-0; PMCID=PMC10147623;
RA   Rasmussen S.V., Wozniak A., Lathara M., Goldenberg J.M., Samudio B.M.,
RA   Bickford L.R., Nagamori K., Wright H., Woods A.D., Chauhan S., Lee C.-J.,
RA   Rudzinski E.R., Swift M.K., Kondo T., Fisher D.E., Imyanitov E.N.,
RA   Machado I., Llombart-Bosch A., Andrulis I.L., Gokgoz N., Wunder J.S.,
RA   Moritake H., Nakamura T., Srinivasa G., Thway K., Jones R.L., Huang P.H.,
RA   Berlow N.E., Schoffski P., Keller C.;
RT   "Functional genomics of human clear cell sarcoma: genomic,
RT   transcriptomic and chemical biology landscape for clear cell sarcoma.";
RL   Br. J. Cancer 128:1941-1954(2023).
//