ID   PC-13
AC   CVCL_B259
SY   PC 13; PC13
DR   cancercelllines; CVCL_B259
DR   CGH-DB; 9184-4
DR   ChEMBL-Cells; CHEMBL3307865
DR   ChEMBL-Targets; CHEMBL614100
DR   Cosmic; 801576
DR   Cosmic; 809128
DR   Cosmic; 844835
DR   Cosmic; 876173
DR   Cosmic; 917996
DR   Cosmic; 946059
DR   Cosmic; 1239926
DR   Cosmic; 2125281
DR   Cosmic; 2668332
DR   IARC_TP53; 11871
DR   PubChem_Cell_line; CVCL_B259
DR   Wikidata; Q54938395
RX   PubMed=1847845;
RX   PubMed=3731100;
RX   PubMed=4094096;
RX   PubMed=10536175;
RX   PubMed=11005564;
RX   PubMed=15185009;
RX   PubMed=15746151;
RX   PubMed=16105816;
RX   PubMed=17511773;
RX   PubMed=19472407;
RX   PubMed=20557307;
CC   From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Leu858Arg (c.2573T>G); ClinVar=VCV000016609; Zygosity=Heterozygous; Note=In 10% of cells (PubMed=16105816).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly334Val (c.1001G>T); Zygosity=Unspecified (PubMed=10536175; PubMed=20557307).
DI   NCIt; C4450; Lung large cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 21
//
RX   PubMed=1847845; DOI=10.1007/BF00685110;
RA   Sasaki Y., Shinkai T., Eguchi K., Tamura T., Ohe Y., Ohmori T.,
RA   Saijo N.;
RT   "Prediction of the antitumor activity of new platinum analogs based on
RT   their ex vivo pharmacodynamics as determined by bioassay.";
RL   Cancer Chemother. Pharmacol. 27:263-270(1991).
//
RX   PubMed=3731100;
RA   Hanai N., Shitara K., Yoshida H.;
RT   "Generation of monoclonal antibodies against human lung squamous cell
RT   carcinoma and adenocarcinoma using mice rendered tolerant to normal
RT   human lung.";
RL   Cancer Res. 46:4438-4443(1986).
//
RX   PubMed=4094096; DOI=10.1093/oxfordjournals.jjco.a039097;
RA   Lee Y.-C., Saijo N., Sasaki Y., Takahashi H., Sakurai M., Ishihara J.,
RA   Hoshi A., Chen K.-M., Hamburger A.W.;
RT   "Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9,
RT   PC-13 and PC-14) and how they influence the results of test for
RT   chemosensitivity to cisplatin in the human tumor clonogenic assay.";
RL   Jpn. J. Clin. Oncol. 15:637-644(1985).
//
RX   PubMed=10536175; DOI=10.3892/ijo.15.5.927;
RA   Fujita T., Kiyama M., Tomizawa Y., Kohno T., Yokota J.;
RT   "Comprehensive analysis of p53 gene mutation characteristics in lung
RT   carcinoma with special reference to histological subtypes.";
RL   Int. J. Oncol. 15:927-934(1999).
//
RX   PubMed=11005564; DOI=10.1038/sj.neo.7900094;
RA   Kohno T., Sato T., Takakura S., Takei K., Inoue K., Nishioka M.,
RA   Yokota J.;
RT   "Mutation and expression of the DCC gene in human lung cancer.";
RL   Neoplasia 2:300-305(2000).
//
RX   PubMed=15185009; DOI=10.1007/s00262-004-0533-9;
RA   Yamaji H., Iizasa T., Koh E., Suzuki M., Otsuji M., Chang H.,
RA   Motohashi S., Yokoi S., Hiroshima K., Tagawa M., Nakayama T.,
RA   Fujisawa T.;
RT   "Correlation between interleukin 6 production and tumor proliferation
RT   in non-small cell lung cancer.";
RL   Cancer Immunol. Immunother. 53:786-792(2004).
//
RX   PubMed=15746151; DOI=10.1093/hmg/ddi092;
RA   Izumi H., Inoue J., Yokoi S., Hosoda H., Shibata T., Sunamori M.,
RA   Hirohashi S., Inazawa J., Imoto I.;
RT   "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in
RT   non-small cell lung cancers.";
RL   Hum. Mol. Genet. 14:997-1007(2005).
//
RX   PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331;
RA   Nagai Y., Miyazawa H., Huqun X., Tanaka T., Udagawa K., Kato M.,
RA   Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K.;
RT   "Genetic heterogeneity of the epidermal growth factor receptor in
RT   non-small cell lung cancer cell lines revealed by a rapid and
RT   sensitive detection system, the peptide nucleic acid-locked nucleic
RT   acid PCR clamp.";
RL   Cancer Res. 65:7276-7282(2005).
//
RX   PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x;
RA   Fukuyama T., Ichiki Y., Yamada S., Shigematsu Y., Baba T., Nagata Y.,
RA   Mizukami M., Sugaya M., Takenoyama M., Hanagiri T., Sugio K.,
RA   Yasumoto K.;
RT   "Cytokine production of lung cancer cell lines: correlation between
RT   their production and the inflammatory/immunological responses both in
RT   vivo and in vitro.";
RL   Cancer Sci. 98:1048-1054(2007).
//
RX   PubMed=19472407; DOI=10.1002/humu.21028;
RA   Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R.,
RA   Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.;
RT   "A gene-alteration profile of human lung cancer cell lines.";
RL   Hum. Mutat. 30:1199-1206(2009).
//
RX   PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x;
RA   Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.;
RT   "Prevalence of human papillomavirus 16/18/33 infection and p53
RT   mutation in lung adenocarcinoma.";
RL   Cancer Sci. 101:1891-1896(2010).
//