ID   UOK124
AC   CVCL_B105
SY   UOK-124; UOK 124
DR   cancercelllines; CVCL_B105
DR   Cosmic; 1330967
DR   Cosmic; 2702366
DR   IARC_TP53; 726
DR   Wikidata; Q54991345
RX   PubMed=1345811;
RX   PubMed=7587394;
RX   PubMed=8319216;
RX   PubMed=8872474;
RX   PubMed=9255309;
CC   Sequence variation: Gene fusion; HGNC; 9343; PRCC + HGNC; 11752; TFE3; Name(s)=PRCC-TFE3 (PubMed=8872474).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (PubMed=8319216).
CC   Misspelling: Re-124; IARC_TP53=726; Note=Not really a misspelling but an assignment of a name based on first author of publication because assignment of correct cell line name was not done correctly.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C6975; Papillary renal cell carcinoma
DI   ORDO; Orphanet_319298; Papillary renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B106 ! UOK124LN
SX   Female
AG   21Y
CA   Cancer cell line
DT   Created: 06-06-12; Last updated: 05-10-23; Version: 15
//
RX   PubMed=1345811;
RA   Anglard P., Trahan E.E. Jr., Liu S., Latif F., Merino M.J., Lerman M.I.,
RA   Zbar B., Linehan W.M.;
RT   "Molecular and cellular characterization of human renal cell carcinoma
RT   cell lines.";
RL   Cancer Res. 52:348-356(1992).
//
RX   PubMed=7587394; DOI=10.1159/000134127;
RA   Shipley J.M., Birdsall S., Clark J., Crew J., Gill S., Linehan W.M.,
RA   Gnarra J.R., Fisher S., Craig I.W., Cooper C.S.;
RT   "Mapping the X chromosome breakpoint in two papillary renal cell
RT   carcinoma cell lines with a t(X;1)(p11.2;q21.2) and the first report
RT   of a female case.";
RL   Cytogenet. Cell Genet. 71:280-284(1995).
//
RX   PubMed=8319216;
RA   Reiter R.E., Anglard P., Liu S., Gnarra J.R., Linehan W.M.;
RT   "Chromosome 17p deletions and p53 mutations in renal cell carcinoma.";
RL   Cancer Res. 53:3092-3097(1993).
//
RX   PubMed=8872474; DOI=10.1093/hmg/5.9.1333;
RA   Sidhar S.K., Clark J., Gill S., Hamoudi R., Crew A.J., Gwilliam R.,
RA   Ross M., Linehan W.M., Birdsall S., Shipley J.M., Cooper C.S.;
RT   "The t(X;1)(p11.2;q21.2) translocation in papillary renal cell
RT   carcinoma fuses a novel gene PRCC to the TFE3 transcription factor
RT   gene.";
RL   Hum. Mol. Genet. 5:1333-1338(1996).
//
RX   PubMed=9255309; DOI=10.1016/S0090-4295(97)00220-3;
RA   Walther M.M., Kleiner D.E., Lubensky I.A., Pozzatti R., Nyguen T.,
RA   Gnarra J.R., Hurley K., Venzon D., Linehan W.M.,
RA   Stetler-Stevenson W.G.;
RT   "Progelatinase A mRNA expression in cell lines derived from tumors in
RT   patients with metastatic renal cell carcinoma correlates inversely
RT   with survival.";
RL   Urology 50:295-301(1997).
//