ID   SK-N-MC-IXC/VCR
AC   CVCL_B0FD
SY   MC-IXC/VCR
DR   Wikidata; Q108821309
RX   PubMed=2566379;
CC   Problematic cell line: Misclassified. Grand-parent cell line (SK-N-MC) was originally thought to be a neuroblastoma cell line but shown to be from an Askin tumor.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28445; Vincristine (VCR).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.170_572del; Zygosity=Unspecified (from parent cell line).
CC   Derived from site: Metastatic; Orbital region; UBERON=UBERON_0004088.
DI   NCIt; C7542; Askin tumor
DI   ORDO; Orphanet_370348; Peripheral primitive neuroectodermal tumor
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1398 ! SK-N-MC-IXC
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 7
//
RX   PubMed=2566379;
RA   Meyers, Marian B.
RA   Grauer, Lana Suzanne
RA   O'Brien, James P.
RA   Safa, Ahmad R.
RT   "Characterization of monoclonal antibodies recognizing a Mr 180,000
RT   P-glycoprotein: differential expression of the Mr 180,000 and Mr
RT   170,000 P-glycoproteins in multidrug-resistant human tumor cells.";
RL   Cancer Res. 49:3209-3214(1989).
//