ID   SFT
AC   CVCL_B0CD
DR   ATCC; CRL-3469
DR   cancercelllines; CVCL_B0CD
DR   Wikidata; Q108821294
RX   PubMed=23843634;
RX   PubMed=29091757;
CC   Population: Caucasian.
CC   Virology: Can be used to evaluate the infectious entry of polyomaviruses (BKPyV, JCPyV, SV40) and human papillomaviruses. Pathogenic variants of the JCPyV virus previously believed to be non-infectious can infect this cell line, especially in the presence of the chemical 3Fax-Peracetyl Neu5Ac (3Fax) (ATCC=CRL-3469).
CC   Doubling time: ~30 hours (ATCC=CRL-3469).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Thr116Leufs*8 (c.346_349delACTT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg342Glufs*3 (c.1024delC); ClinVar=VCV000428885; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P03070; SV40 large T antigen.
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Brain, right temporo-parietal lobe.
DI   NCIt; C3796; Gliosarcoma
DI   ORDO; Orphanet_251576; Gliosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1691 ! SF539
SX   Female
AG   34Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 05-10-23; Version: 7
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RX   PubMed=23843634; DOI=10.1128/JVI.01189-13;
RA   Pastrana D.V., Ray U., Magaldi T.G., Schowalter R.M., Cuburu N.,
RA   Buck C.B.;
RT   "BK polyomavirus genotypes represent distinct serotypes with distinct
RT   entry tropism.";
RL   J. Virol. 87:10105-10113(2013).
//
RX   PubMed=29091757; DOI=10.1016/j.celrep.2017.10.027;
RA   Geoghegan E.M., Pastrana D.V., Schowalter R.M., Ray U., Gao W., Ho M.,
RA   Pauly G.T., Sigano D.M., Kaynor C., Cahir-McFarland E.,
RA   Combaluzier B., Grimm J., Buck C.B.;
RT   "Infectious entry and neutralization of pathogenic JC
RT   polyomaviruses.";
RL   Cell Rep. 21:1169-1179(2017).
//